Laugier-Hunziker syndrome

A healthy 37-year-old woman presented to the clinic with a 1-year history of progressive asymptomatic hyperpigmented macules on the lips and longitudinal hyperpigmentation of the left thumb extending to the cuticle. There was no relevant drug or positive family history or evidence of other pigmented lesions. On examination, there was linear, brownish, reticular pattern on both inner aspect of her lips and longitudinal melanonychia in the left thumb extending to the cuticle on the middle aspect of the nail. Laboratory tests, Chest X-ray and abdominal ultrasound were normal. Colonoscopic findings were negative for any gastrointestinal pathology or tumorous formations associated with oral hyperpigmentations. Based on the endocrinologist's exam adrenal insufficiency was ruled out and histological examination of the lip lesions revealed non-specific changes such as acantosis and hyperpigmentation of the basal layer. By excluding the other differentials, diagnosis of Laugier-Hunziker syndrome was made. Laugier-Hunziker syndrome is a benign chronic progressive asymptomatic hyperpigmented macules onssssssssssss the lips and buccal mucosa and often is associated with longitudinal melanonychia (A). The main differential diagnoses are drug induced hyperpigmentation, racial pigmentation, smoker’s melanosis, Addisons disease and Peutz-Jeghers syndrome (B). As a diagnosis of exclusion Laugier-Hunziker syndrome always should be considered in the differential diagnosis of patients with mucocutaneous and nail hyperpigmentation without any systemic symptoms, specially in the middle-aged groups (A,B). Therefore, its diagnosis can easily exclude other severe pigmentary disorders and avoid unnecessary diagnostic procedures. Treatment is not necessary exept for cosmetic purposes (B).Pan African Medical Journal 2016; 2

Deep Extractive Oxidative Desulfurization of Model Oil/Crude Oil using Different Keggin Heteropoly Acids Supported on K10 Montmorillonite

This study investigated the catalytic performance of three polyoxometalates (H3PMo12O40 (PMo), H3PW12O40 (PW), and H4SiW12O40 (SiW)) supported on montmorillonite K10 for oxidative desulfurization (ODS) of thiophenic model oil, crude oil, and gasoline. Experimental results revealed that PW exhibited higher activity than PMo and SiW. The best solvent for mixed model oil was found to be EtOH, while MeCN was optimal for crude oil to remove oxidized sulfur compounds in a biphasic system under atmospheric pressure at 75°C in the presence of H2O2 as an oxidating agent. Using PW/K10 as the catalyst, the conversion of mixed model/EtOH and crude oil/MeCN reached 98.76% and 51.36%, respectively, under optimal conditions for 80 minutes. To investigate the impact of real oil composition on the desulfurization process, various unsaturated and N-compounds (pyrrole and pyridine) were added to mixed model oil. Finally, PW/K10 was recycled five times, and the results indicated no significant decrease in catalytic activity. Introductio

{6,6′-Dimeth­oxy-2,2′-[4,5-dimethyl-o-phenyl­enebis(nitrilo­methyl­idyne)]diphenolato}nickel(II)

In the title Schiff base complex, [Ni(C24H22N2O4)], the NiII atom has a slightly distorted square-planar coordination environment. The dihedral angles between the central benzene ring and the two outer rings are 7.62 (16) and 9.78 (17)°. The crystal structure is stabilized by inter­molecular C—H⋯O hydrogen bonds and π–π inter­actions with a centroid–centroid distance of 3.8218 (19) Å

Long-term dynamic analysis based on Landsat imagery in the Gorgan Bay- Gomishan Wetland, Iran

Coastal ecosystems are very dynamic and their changes occur relatively quickly due to the collision of two dynamic environments of land and sea. Gorgan Bay and Gomishan Wetland are unique ecosystems in the south-eastern part of the Caspian Sea. In this study periodic changes in the ecosystems of Gomishan Wetland and Gorgan Bay were evaluated over a period of 40 years using Landsat satellite imagery from 1978-2018. MSS, TM and OLI imagery along with NDWI index were used. The results show that the fluctuations in both ecosystems were consistent and the coastline changes were greater in the near-land areas. Based on the results, the highest area of ​​water in both ecosystems was obtained in 1997 (210.43 and 528.97 km2 for Gomishan Wetland and Gorgan Bay, respectively). These ecosystems also exhibited the lowest water area in 1978. In general, it can be conclude that remote sensing was an efficient tool in monitoring and managing coastal ecosystems

Determination of Lipid Profile in Preschool Children and Pre- college Students with Beta-thalassemia Minor and Control Group

Thalassemias are heterogeneous group of inherited anemias caused by various mutations in the genes encoding the synthesis of α α α α α or β β β β β-chains of hemoglobin. It seems that there are some aspects in thalassemia that protect minor thalassemic patients from coronary heart disease. From those aspects we can count such as low serum lipoproteins, low arterial hypertension, and anemia and so on. A cross sectional descriptive and analytical study was designed to compare some lab data of minor thalassemic students and others. So 570 preschool children (6-7 years of age) and 450 pre-college students (17-19 year of age) in 4 educational discrete of Shiraz (center of Fars province-Iran) were selected in a random cluster manner were tested for CBC and serum lipids (TG, cholesterol, LDL, HDL) and were screened for minor thalassemia by CBC and HbA 2 (by column chromatography). For definition of minor thalassemia as cut-off Point HbA 2 ≥ ≥ ≥ ≥ ≥ 3.5% was accepted. After selection of minor thalassemic patients, serum lipids (TG, cholesterol, HDL, LDL) for them and control group were checked. According to this study in preschool children there is no significant difference between minor thalassemic patients and control group. In pre-collage students TG in control group is lesser than minor beta thalassemic patients (P value=0.004); but total cholesterol and LDL in patients group is lesser than control group and difference is significant. Total cholesterol and LDL in pre-college beta thalassemia minor students are lesser than control group. But TG in control group is lesser than patients group. According to this study in preschool children there is no significant difference in serum lipids between minor thalassemic students and control group

Exercise Behavior and Self-Efficacy of Medical Students Based on Stages of Change Model

Introduction: Despite the benefits of exercisemany people in different countries specially students, have not enough physical activity. The aim of this research is to study exercise behavior of medical students in Rafsanjan University of Medical Sciences based on stages of change model and assess itsrelationship with students’ self-efficacy.Method: All of the 309 students of Rafsanjan University of Medical Sciences participated in this cross-sectional study. The data collection methodwas a questionnaire which consistedof four parts: demographic characteristics, the pattern of weekly physical activity, the level of exercise behavior which was based on stages of change model and finally the questions which assess exercises self-efficacy. Results: Atotalof 309students(46.6% male and 53.4% female) participated in this study. The mean (SD) of their age was 21.57 (2.20). Based on the stages of change model 117 (37.9%) students were on the pre-contemplation stage. 78 (25.2%), 45 (14.6%), 27 (8.7%) and 42 (13.6%) students were on the contemplation, readiness, action and maintenance stage, respectively. The results showed that there was a significant positive correlation between students’ exercise self-efficacyand their stages of change (p< 0.001).Conclusion: Based on the results of this study, exercise self-efficacy had an important role in students’ exercise behavior. Therefore, it seems to be important for related institutions such as Physical Education Organization tofocus a part of their activities on improving thelevel of exercise self-efficacy in students. Declaration of Interest: Non

5,5′-Dimeth­oxy-2,2′-[4,5-dimethyl-o-phenyl­enebis(nitrilo­methyl­idyne)]diphenol

In the crystal structure of the title compound, C24H24N2O4, the dihedral angles between the central and the two outer benzene rings are 48.12 (8) and 21.44 (8)°. Intra­molecular O—H⋯N hydrogen bonding generates S(6) rings

3,3′-Dimeth­oxy-2,2′-[(4,5-dimethyl-o-phenyl­ene)bis­(nitrilo­methanylyl­idene)]diphenol

The asymmetric unit of the title compound, C24H24N2O4, comprises two crystallographically independent mol­ecules A and B. The dihedral angles between the central dimethyl-substituted benzene ring and the two outer benzene rings are 49.5 (1) and 5.06 (11)° in mol­ecule A, and 42.55 (8) and 5.77 (9)° in mol­ecule B. In each mol­ecule, two strong intra­molecular O—H⋯N hydrogen bonds generate two S(6) ring motifs. The crystal structure is further stabilized by inter­molecular π–π [centroid–centroid distances of 3.591 (1)–3.876 (1) Å] inter­actions

Association of rs1042522 SNP with Clinicopathologic Factors of Breast Cancer Patients in the Markazi Province of Iran

BACKGROUND: The nucleotide changes in different genetic loci increased the incidence risk of breast cancer. AIM: The aim of present study was to investigate genotype distribution at codon 72 of the TP53 gene (rs1042522) in breast cancer patients to achieve a potential diagnostic marker related to some demographic feathers. METHODS: In our case-control study, blood samples were collected from a total of 34 patients harboured breast cancer. DNA was extracted, and nested-PCR was performed. Products were digested with AccII and subsequently were sequenced. Results were compared with samples characteristics. RESULTS: The PCR results indicated the correct implementation of extraction and amplification protocol. The genotypic distribution at codon 72 of TP53 in control group was 20%, 62.4% and 16.6% for Arg (wildtype), Arg/Pro (heterozygous) and Pro (homozygous variant) respectively. Also, this distribution in the patient group was 23.52% homozygous, 50% heterozygous, and 26.47% another homozygous variant (Adjusted odds ratio: 1.12 and 95%CI = 0.57 to 2.2, P = 0.03). The absence of Arg at codon 72 of TP53 is relevant with age higher than 40 years and metastasis to other organs. CONCLUSION: Polymorphism at codon 72 of TP53 was associated with high-grades of breast cancer risk and different responses to chemotherapy treatment. It is recommended genotype distribution of codon 72 of TP53 before chemotherapy